Targeting the endoplasmic reticulum with a membrane-interactive luminescent ruthenium(ii) polypyridyl complex
نویسندگان
چکیده
منابع مشابه
Targeting pathways to the endoplasmic reticulum membrane.
The targeting of proteins to the endoplasmic reticulum (ER) membrane is the first step in the secretory pathway through which proteins are transported to the outside of the cell, the plasma membrane, and the luminal spaces and membranes of the endomembrane system. Proteins that undergo this targeting event carry a stretch of hydrophobic amino acids, usually at the amino terminus, that constitut...
متن کاملTargeting the endoplasmic reticulum with a membrane-interactive luminescent ruthenium(ii) polypyridyl complex† †Electronic supplementary information (ESI) available: Experimental details, characterization of 2 and Fig. S1–S6. See DOI: 10.1039/c3sc51725j Click here for additional data file.
The characterization and bioactivity of the dinuclear ruthenium(ii) complex [(Ru(DIP)2)2(tpphz)]4+ (DIP = 4,7-diphenyl-1,10-phenanthroline and tpphz = tetrapyrido[3,2-a:2',3'-c:3'',2''-h:2''',3'''-j]phenazine) is reported. This new complex is found to be luminescent in acetonitrile, where excitation into MLCT (metal-to-ligand charge-transfer) bands in the visible area of the spectrum (λex = 450...
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SRP-dependent and SRP-independent targeting routes deliver precursor proteins to the ER membrane translocon. These precursors are translocated into (for membrane proteins) and across (for secretory protein) the ER membrane via aqueous channels composed of oligomers of the Sec61 complex. Both ends of the ER translocon are 'gated' and the opening and closing of these gates are closely regulated. ...
متن کاملMembrane protein insertion at the endoplasmic reticulum.
Integral membrane proteins of the cell surface and most intracellular compartments of eukaryotic cells are assembled at the endoplasmic reticulum. Two highly conserved and parallel pathways mediate membrane protein targeting to and insertion into this organelle. The classical cotranslational pathway, utilized by most membrane proteins, involves targeting by the signal recognition particle follo...
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Proteins to be secreted from eukaryotic cells are delivered to the extracellular space after trafficking through a secretory pathway composed of several complex intracellular compartments. Secretory proteins are first translocated from the cytosol into the endoplasmic reticulum (ER), after which they travel by vesicular trafficking via various intermediate destinations en route to the plasma me...
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2013
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c3sc51725j